The RESILIENT study randomized stroke patients in Brazil with large vessel occlusion to mechanical thrombectomy within 8 hours of symptom onset. The trial demonstrated the efficacy of mechanical thrombectomy in the Brazilian healthcare setting. Patients were enrolled if ASPECTS ≥6 and there was no malignant collateral profile on CTA. e-ASPECTS was specified in the trial protocol for patient selection and was used prospectively in multiple trial sites.